Sometimes when trying to access your favourite website, Chrome may respond with "This page isn't working, if the problem continues please contact the site owner. HTTP error 400".  Therefore making it impossible to access the desired site from within Chrome's normal mode.

A bit weird, I ran into this situation earlier today, I needed to change the thousand grouping symbol from " .  "   to  "  ,  " but could not find the right section to change from, oddly the option to change this symbol was not in the application preference. After some fiddling around, finally got it to change. The solution was to change it from System Preference as shown below.